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HDAC1 and HDAC2 contribute to several nuclear multimeric coregulatory complexes, including CoREST

J Exp Bot 67:391403 Pinton R, Cakmak I, Marschner H (1994) Zinc deficiency enhanced NAD(P)H-dependent superoxider radical production in plasma membrane vesicles isolated from roots of bean plants

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This indicates a lower reducing potential in the ER lumen compared to other compartments, which facilitates protein folding and disulfide bond formation in nascent proteins

As expected by the increased striatal DA, pathways signifying activation of signalling by G-protein-coupled receptors, transmission across chemical synapses and calcium signalling were all positively enriched at 3 months in iSPN + mut (Supplementary Table 1a), whereas genes associated with metabolic pathways such as oxidative phosphorylation (OxPhos) and respiratory electron transport ATP synthesis were significantly downregulated in iSPN + mut compared to iSPN+wt at 3 months (Fig